AfaPhos1
AfaPhos1 is a new, Afatinib (HY-10261) -based EGFR PhosTAC. AfaPhos1 induces EGFR dephosphorylation at both pY1068 and pY845. AfaPhos1 induces Apoptosis. AfaPhos1 has anticancer activity against non-small cell lung cancer[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Drug Derivative; EGFR
Related Pathways
Apoptosis; JAK/STAT Signaling; Others; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=C(COC1=CC([C@@H](CCC2=CC=C(C(OC)=C2)OC)OC([C@@H]3CCCCN3C([C@H](C4=CC(OC)=C(C(OC)=C4)OC)CC)=O)=O)=CC=C1)NCCOCCOCCN(C/C=C/C(NC5=CC6=C(C=C5OC)N=CN=C6NC7=CC=C(C(Cl)=C7)F)=O)C
Molecular Formula
C64H77ClFN7O14
Molecular Weight
1222.79
References & Citations
[1]Hu Z, et al. EGFR targeting PhosTACs as a dual inhibitory approach reveals differential downstream signaling. Sci Adv. 2024 Mar 29;10 (13) :eadj7251.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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