HSN608

HSN608 is an orally active, potent RET G810 mutant inhibitor. HSN608 inhibits G810C, G810R, G810D. HSN608 induces Apoptosis. HSN608 inhibits the Selpercatinib (HY-114370) -resistant RET (G810C) CDX tumors[1].

Product Specifications

CAS Number

[2234239-90-6]

UNSPSC

12352005

Target

Apoptosis; RET

Related Pathways

Apoptosis; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

O=C(NC1=CC=C(C(C(F)(F)F)=C1)CN2CCN(C)CC2)C3=CC(C#CC4=C5C=CC=NC5=C(N=C4)N)=CN=C3

Molecular Formula

C29H26F3N7O

Molecular Weight

545.56

References & Citations

[1]Khatri U, et al. Targeting RET Solvent-Front Mutants with Alkynyl Nicotinamide-Based Inhibitors. Mol Cancer Ther. 2023 Jun 1;22 (6) :717-725.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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