JPS004

JPS004 is a HDAC1-3 PROTAC degrader. JPS004 can induce degradation of HDAC1-3 and induce histone acetylation. JPS004 can induce cancer cells apoptosis. JPS004 can be used for the research of cancer[1]. (Structure Note: Pink: HDAC1-3 ligand (HY-50934) ; Blue: VHL ligand (HY-125845) ; HDAC1-3 ligand-Linker: (HY-176905) )

Product Specifications

CAS Number

[2559747-12-3]

UNSPSC

12352005

Target

Apoptosis; HDAC; PROTACs

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

NC(C=CC=C1)=C1NC(C(C=C2)=CC=C2NC(CCCCCCCCCCC(N[C@@H](C(C)(C)C)C(N3[C@@H](C[C@H](C3)O)C(NCC4=CC=C(C5=C(N=CS5)C)C=C4)=O)=O)=O)=O)=O

Molecular Formula

C47H61N7O6S

Molecular Weight

852.10

References & Citations

[1]India M. Baker, et al. Comprehensive Transcriptomic Analysis of Novel Class I HDAC Proteolysis Targeting Chimeras (PROTACs) . Biochemistry 2023, 62, 3, 645–656