LATS-IN-2

LATS-IN-2 is an efficiently acting LATS (large tumor suppressor kinase) inhibitor. LATS-IN-2 shows potent inhibitory activity against LATS1 with an IC50 value of 1.3 nM. LATS-IN-2 suppresses the phosphorylation of YAP by inhibiting LATS kinase activity. LATS-IN-2 increases the thickness of the epidermis in mice. LATS-IN-2 can be used for the study of ocular diseases such as limbal stem cell deficiency and corneal endothelial dysfunction[1].

Product Specifications

CAS Number

[2248728-49-4]

UNSPSC

12352005

Target

YAP

Related Pathways

Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Others

Purity

99.4500

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC1(CC1)NC2=NC(C3=CNN=C3C)=NC4=C2C=CN=C4

Molecular Formula

C15H16N6

Molecular Weight

280.33

References & Citations

[1]BEHNKE, Dirk, et al. 6-6 FUSED BICYCLIC HETEROARYL COMPOUNDS AND THEIR USE AS LATS INHIBITORS. WO 2018/198077 A2. World Intellectual Property Organization (WIPO) . 01 November 2018.