Rodin-B

Rodin-B is a selective histone deacetylase (HDAC) -co-repressor of repressor element-1 silencing transcription factor (CoREST) complex inhibitor with an IC50 value of 0.50 μM for the CoREST complex, 0.27 μM for HDAC1, and 0.28 μM for HDAC2. Rodin-B increases the acetylation level of histone H3K9, upregulates the expression of neuron-related genes, thereby promoting the increase in dendritic spine density, the colocalization of synaptic proteins (SV2A and PSD95), and the improvement of hippocampal long-term potentiation (LTP), exerting synaptic protection and repair activity. Rodin-B is promising for research of neurodegenerative diseases related to synaptic dysfunction, especially Alzheimer’s disease[1].

Product Specifications

UNSPSC

12352005

Target

HDAC

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Smiles

COCCN1C=C2CN(C(NC3=NC(C4=CC=C(F)C=C4F)=CC=C3N)=O)CC2=N1

Molecular Formula

C20H20F2N6O2

Molecular Weight

414.41

References & Citations

[1]Fuller NO, et al. CoREST Complex-Selective Histone Deacetylase Inhibitors Show Prosynaptic Effects and an Improved Safety Profile To Enable Treatment of Synaptopathies. ACS Chem Neurosci. 2019 Mar 20;10 (3) :1729-1743.