VVD-442

VVD-442 is a covalent RAS-PI3K inhibitor. VVD-442 binds covalently to cysteine 242 in the RAS binding domain of PI3K p110α and blocks RAS/PI3K interaction. VVD-442 can be used cancers like breast cancer research[1].

Product Specifications

CAS Number

[3055318-88-9]

UNSPSC

12352005

Target

PI3K; Ras

Related Pathways

GPCR/G Protein; MAPK/ERK Pathway; PI3K/Akt/mTOR

Field of Research

Cancer

Smiles

BrC1=CC(C2=C(Cl)C=CC=C2)=C(S(N3CCC(C(N[C@H](C)/C=C\S(C)(=O)=O)=O)(F)CC3)(=O)=O)C=C1

Molecular Formula

C23H25BrClFN2O5S2

Molecular Weight

607.94

References & Citations

[1]Klebba JE, et al. Covalent inhibitors of the RAS binding domain of PI3Kα impair tumor growth driven by RAS and HER2. bioRxiv [Preprint]. 2024 Dec 20:2024.12.17.629001.