ZN148

ZN148 is a zinc-chelating synthetic metallo-β-lactamase (MBL) inhibitor which attenuates MBL-mediated carbapenem resistance. ZN148 can restore the in vitro clinical susceptibility to carbapenems in >98% of a large international collection of MBL-producing clinical Enterobacterales strains. ZN148 can be utilized in research on anti MBL-producing bacteria[1].

Product Specifications

CAS Number

[2190527-04-7]

UNSPSC

12352005

Target

Beta-lactamase

Related Pathways

Anti-infection

Field of Research

Infection

Smiles

OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)CN(C)C(C(C=N1)=CC=C1CN(CC2=CC=CC=N2)CC3=CC=CC=N3)=O

Molecular Formula

C26H33N5O6

Molecular Weight

511.57

References & Citations

[1]Samuelsen Ø, et al. ZN148 Is a Modular Synthetic Metallo-β-Lactamase Inhibitor That Reverses Carbapenem Resistance in Gram-Negative Pathogens In Vivo. Antimicrob Agents Chemother. 2020 May 21;64 (6) :e02415-19.