C3361

C3361 is a moderate specific Plasmodium falciparum hexose transporter 1 (PfHT1) and Plasmodium berghei hexose transporter 1 (PbHT1) inhibitor with Ki values of 8.6 and 9.4 μM. C3361 inhibits TgGT1 with a Ki of 82 μM. C3361 attenuates hepatic (IC50 = 15 μM) and ookinete development of P. berghei. C3361 can suppress the growth of blood-stage parasites. C3361 can be used for the research of infection, such as malaria[1][2].

Product Specifications

CAS Number

[91042-00-1]

UNSPSC

12352005

Target

Parasite

Related Pathways

Anti-infection

Field of Research

Infection

Smiles

C=CCCCCCCCCCO[C@H]1[C@@H]([C@H](OC([C@@H]1O)O)CO)O

Molecular Formula

C17H32O6

Molecular Weight

332.43

References & Citations

[1]Huang J, et al. Orthosteric-allosteric dual inhibitors of PfHT1 as selective antimalarial agents. Proc Natl Acad Sci U S A. 2021 Jan 19;118 (3) :e2017749118.|[2]Blume M, et al. A constitutive pan-hexose permease for the Plasmodium life cycle and transgenic models for screening of antimalarial sugar analogs. FASEB J. 2011 Apr;25 (4) :1218-29.