TBE56

TBE56, a molecular glue, is a BACH1 degrader, with an EC50 of 44 nM. TBE56 is a weak NRF2 inducer and the biotinylated TBE31. TBE56 interacts and promotes the degradation of BACH1 via a mechanism involving the E3 ligase FBX022. TBE56 reduces intracellular Fe2+ accumulation, ROS generation, and malondialdehyde (MDA) content, while increasing GSH/GSSG ratio and upregulating GPX4 in Prominin-2-overexpressed BMSCs. TBE56 significantly ameliorates intervertebral disc degeneration (IVDD) in puncture-induced SD rat IVDD model. TBE56 can be used for the study of intervertebral disc degeneration (IVDD) [1][2].

Product Specifications

UNSPSC

12352005

Target

Reactive Oxygen Species (ROS)

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Smiles

C#C[C@@]12C([C@]3([C@]([C@](C)(C(C(C#N)=C3)=O)COC(CCCCCNC(CCCC[C@H]4[C@]5([H])[C@](NC(N5)=O)([H])CS4)=O)=O)([H])CC1)C)=CC(C(C#N)=C2)=O

Molecular Formula

C37H43N5O6S

Molecular Weight

685.83

References & Citations

[1]Moreno R, et al. Biotinylation of an acetylenic tricyclic bis (cyanoenone) lowers its potency as an NRF2 activator while creating a novel activity against BACH1. Free Radic Biol Med. 2022 Oct;191:203-211.|[2]Xu Y, et al. Prominin-2/FBXO22/BACH1 axis protects bone marrow mesenchymal stem cells against TBHP-induced ferroptosis and ameliorates intervertebral disc degeneration. Stem Cell Res Ther. 2025 Jul 1;16 (1) :340.