S1PR5-IN-1

S1PR5-IN-1 (Compound 7a) is a selective and BBB-penetrable S1PR5 inhibitor with an IC50 of 85.4 nM. S1PR5-IN-1 has a superior binding capacity on S1PR5 with Kds of 2.2, 4.6, and 27.6 nM for recombinant human S1PR5 cell membranes, C57BL/6 mouse brain, and human cerebral cortex, respectively. S1PR5-IN-1 can be used for neurodegenerative disorders like multiple sclerosis research[1].

Product Specifications

UNSPSC

12352005

Target

LPL Receptor

Related Pathways

GPCR/G Protein

Field of Research

Neurological Disease

Smiles

CC(C)([C@@H]1CC[C@@H](OC2=CC(F)=C3C(C=CC=C3)=C2CN4CCC(CC4)C(O)=O)CC1)C

Molecular Formula

C27H36FNO3

Molecular Weight

441.58

References & Citations

[1]Lang J, et al. Design and Synthesis of Novel PET Radiotracers for Imaging Sphingosine-1-Phosphate Receptor 5 (S1PR5) in the Brain. J Med Chem. 2025 Jun 26;68 (12) :12991-13018.