ANT2681

ANT2681 is a potent NDM inhibitor with a Ki value of 0.04 μM against NDM-1. ANT2681 also inhibits other MBLs, such as VIM-1 and IMP-1 with Ki values of 0.63 μM and 3.81 μM, respectively. ANT2681 can be used in combination with Meropenem (HY-13678) to inhibit infections caused by NDM-producing Enterobacteriaceae[1].

Product Specifications

CAS Number

[2270184-16-0]

UNSPSC

12352211

Target

Bacterial; Beta-lactamase

Related Pathways

Anti-infection

Field of Research

Infection

Smiles

O=C(C1=C(NS(=O)(C2=CC(F)=C(C(F)=C2)NC(NNC(N)=N)=O)=O)SC=N1)O

Molecular Formula

C12H11F2N7O5S2

Molecular Weight

435.39

References & Citations

[1]Davies DT, et al. ANT2681: SAR Studies Leading to the Identification of a Metallo-β-lactamase Inhibitor with Potential for Clinical Use in Combination with Meropenem for the Treatment of Infections Caused by NDM-Producing Enterobacteriaceae. ACS Infect Dis. 2020 Sep 11;6 (9) :2419-2430.