SG3683

SG3683 is a DNA-targeted cytotoxic agent belonging to pyrrolobenzodiazepine (PBD) dimers. SG3683 exerts antitumor activity with an IC50 value of 0.74 nM in MDA-MB-436 cells. SG3683 is promising for research of cancers, such as breast cancer[1].

Product Specifications

UNSPSC

12352005

Target

DNA Alkylator/Crosslinker; DNA/RNA Synthesis

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=C1C2=CC(OC)=C(OCC3=CC(COC4=C(C=C5C(N=C[C@@]6([H])N(C=C(C6)C)C5=O)=C4)OC)=CC(C#CCNC(CCOCCOCCOCCOCCNC(CC7=CC=C(N8C(C=CC8=O)=O)C=C7)=O)=O)=C3)C=C2N=C[C@@]9([H])N1C=C(C9)C

Molecular Formula

C62H65N7O14

Molecular Weight

1132.22

References & Citations

[1]Li Q, et al. Improved Inhibition of Tumor Growth by Diabody-Drug Conjugates via Half-Life Extension. Bioconjug Chem. 2019 Apr 17;30 (4) :1232-1243.