Y-99
Y-99 is a PORCN inhibitor with an IC50 of 155.4 nM against the Wnt/β-catenin signaling pathway. Y-99 inhibits the expression of p-LRP6, β-catenin, and c-Myc[1].
Product Specifications
CAS Number
[2034334-74-0]
UNSPSC
12352005
Target
C-Myc; Porcupine; Wnt; β-catenin
Related Pathways
Apoptosis; Stem Cell/Wnt
Field of Research
Cancer
Smiles
O=C(NCC1=NC(C2CCC(F)(F)CC2)=NO1)C3=NOC(C4=CC=CN=C4)=C3
Molecular Formula
C18H17F2N5O3
Molecular Weight
389.36
References & Citations
[1]Yang X, et al. Discovery and Identification of a Novel PORCN Inhibitor via Structure-Based Virtual Screening. ACS Chem Biol. 2025 Jun 20;20 (6) :1319-1332.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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