DDL-357
DDL-357 is a potent secreted clusterin enhancer. DDL-357 reduces phospho-tau in brain and improves memory in the murine 3xTg-AD model[1].
Product Specifications
CAS Number
[3077900-08-1]
UNSPSC
12352005
Target
Tau Protein
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Concentration
10mM
Purity
98.31
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC1=NN=C2[C@H](CC(OC3CC3)=O)N=C(C4=CC=C(Cl)C=C4)C5=C(SC(C)=C5C)N21
Molecular Formula
C22H21ClN4O2S
Molecular Weight
440.95
References & Citations
[1]Cohn W, et al. Discovery of a small molecule secreted clusterin enhancer that improves memory in Alzheimer's disease mice. NPJ Drug Discov. 2025;2 (1) :7.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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