SDH-IN-27
SDH-IN-27 (Compound Q18) is a succinate dehydrogenase inhibitor (SDHI) (IC50: 9.7 mg/L) . SDH-IN-27 induces mycelial morphology changes and lipid peroxidation, and exhibits antifungal activity against C. camelliae (EC50: 6.0 mg/L) . SDH-IN-27 is an ergosterol biosynthesis inhibitor (EBI) that binds to the active site of CYP51, ultimately leading to cell death of pathogenic fungi[1].
Product Specifications
UNSPSC
12352005
Target
Fungal
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Smiles
CCC1=C(N2C(CCl)=C(C(NC3=NC=CC=N3)=O)C=N2)C=CC=C1
Molecular Formula
C17H16ClN5O
Molecular Weight
341.79
References & Citations
[1]Chen K, et al. Synthesis and Activity of Novel Pyrazole/Pyrrole Carboxamides Containing a Dinitrogen Six-Membered Heterocyclic as Succinate Dehydrogenase and Ergosterol Biosynthesis Inhibitors against Colletotrichum camelliae. J Agric Food Chem. 2025 May 7;73 (18) :10914-10922.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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