VS1150
VS1150 (Compound 11) is a BCR-ABL-targeting phosphorylation-inducing chimeric small molecule (PHICS) . VS1150 significantly inhibits oncogenic kinase BCR-ABL signaling by inducing inhibitory phosphorylation at its Y253 (EC50: 69 nM), subsequently triggering cell apoptosis. VS1150 also inhibits other oncogenic ABL fusions and drug-resistant mutants like T315I. VS1150 can be used for chronic myeloid leukemia (CML) and other ABL fusion-driven cancers research[1].
Product Specifications
CAS Number
[2855238-97-8]
UNSPSC
12352005
Target
Apoptosis; Bcr-Abl; Caspase; ERK; PARP; STAT
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; JAK/STAT Signaling; MAPK/ERK Pathway; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=C(C1=CN=C(NCCOCCOCCNC2=NC=C(C(NC3=NN(C4=CC=C(Cl)C(Cl)=C4)CC3)=O)C(C)=N2)N=C1C)NC5=NN(C6=CC=C(Cl)C(Cl)=C6)CC5
Molecular Formula
C36H38Cl4N12O4
Molecular Weight
844.58
References & Citations
[1]Merz M M, et al. Phosphorylation-inducing chimera rewires oncogenic kinase to trigger apoptosis[J]. bioRxiv, 2025: 2025.06. 13.659082.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Bcr-Abl; Caspase 8; STAT5
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