AH001
AH001 is a orally active RhoA inhibitor, which binds a cryptic pocket proximate to GDP within RhoA with a KD of 73.16 nM. AH001 interacts with GDP, stabilizing RhoA’s interaction with its endogenous inhibitor, RhoGDIα. AH001 reduces the downstream MRTFA nuclear translocation and downregulates fibrosis/hypertrophy proteins. AH001 mitigates myocardial remodeling in multiple HF animal models, and in the 3D myocardial tissue model. AH001 exerts its cardioprotective effects through the RhoA-RhoGDIα axis, effectively inhibiting downstream RhoA activation signaling[1].
Product Specifications
CAS Number
[1456769-95-1]
UNSPSC
12352005
Target
Ras
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Smiles
CCC1=CC=CC([C@@H](O)CO)=C1
Molecular Formula
C10H14O2
Molecular Weight
166.22
References & Citations
[1]Mengzhu Xue, et al. Inhibiting RhoA Activation via GDP-state Stabilization to Relieve Heart Failure. bioRxiv. June 07, 2025
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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