TH10184
TH10184 is a NUDT5 inhibitor. TH10184 can be conjugated with VH032 (HY-125845) and linker (HY-W001958) to synthesize PROTAC NUDT5 degrader DDD2 (HY-176261) [1].
Product Specifications
CAS Number
[2271044-59-6]
UNSPSC
12352005
Target
Ligands for Target Protein for PROTAC
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
COC(C=C1C(O2)=NN=C2CN3C(C(N(C(N4C)=O)C)=O)=C4N=C3N5CCNCC5)=C(C=C1)C
Molecular Formula
C22H26N8O4
Molecular Weight
466.49
References & Citations
[1]Seher Alam, et al. A cell-based degrader assessment platform facilitates discovery of functional NUDT5 PROTACs. bioRxiv. June 19, 2025.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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