ROR1-IN-2

ROR1-IN-2 (compound 9I) is a potent and selective ROR1 inhibitor. ROR1-IN-2 exhibits antiproliferative activity in multiple cancer cells. ROR1-IN-2 significantly suppresses tumor growth in vivo[1].

Product Specifications

UNSPSC

12352005

Target

ROR

Related Pathways

Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

CC(NC1=CC=C(C=C1)C2=CC=CC(NC3=C(C=CC(C(NC4=CC5=C(OCCO5)C=C4)=O)=C3)C)=C2)=O

Molecular Formula

C30H27N3O4

Molecular Weight

493.55

References & Citations

[1]Zheng, Q., et al. Structure-directing optimization of N- (2, 3-dihydrobenzo [b][1, 4] dioxin-6-yl) benzamide derivatives as selective receptor tyrosine kinase-like orphan receptor 1 (ROR1) inhibitors for cancer therapy. European Journal of Medicinal Chemistry, 117755.