BBDDL2204

BBDDL2204 (compound 13) is a potent and selective EZH2 covalent inhibitor. BBDDL2204 inhibits EZH2Y641F with an IC50 of 2.5 nM[1].

12352005

Histone Methyltransferase

Epigenetics

Cancer

CC1=C(C=C(C=C1C(NCC2=C(C=C(NC2=O)C)SC)=O)C3=C(C=C(C=C3)CN4CCOCC4)NC(C=C)=O)N(C5CCOCC5)CC

C37H47N5O5S

673.86

[1]Zhang Y, et al. Discovery of Highly Potent and Selective EZH2 Covalent Inhibitors via Incorporating Basic Amines. J Med Chem. 2025 May 8.

Room temperature

Reference compound1

No Development Reported

Curated Selection

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