Bictegravir-d7
Bictegravir-d7 (GS-9883-d7) is deuterium labeled Bictegravir. Bictegravir (GS-9883) is a potent inhibitor of HIV-1 integrase with an IC50 of 7.5 nM.
Product Specifications
CAS Number
[2171092-56-9]
Product Name Alternative
GS-9883-d7
UNSPSC
12352005
Target
HIV; HIV Integrase; Isotope-Labeled Compounds
Related Pathways
Anti-infection; Metabolic Enzyme/Protease; Others
Applications
COVID-19-anti-virus
Field of Research
Infection
Smiles
O=C1N2[C@@](O[C@@]3([2H])C[C@]2([2H])CC3)([2H])C([2H])([2H])N4C1=C(C(C(C(NC([2H])([2H])C5=C(C=C(C=C5F)F)F)=O)=C4)=O)O
Molecular Formula
C21H11D7F3N3O5
Molecular Weight
456.42
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Tsiang M, et al. Antiviral Activity of Bictegravir (GS-9883), a Novel Potent HIV-1 Integrase Strand Transfer Inhibitor with an Improved Resistance Profile. Antimicrob Agents Chemother. 2016 Nov 21;60 (12) :7086-7097.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Curated Selection
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