Sulphostin
Sulphostin is a covalent inhibitor of dipeptidyl peptidase 4 (DPP4), dipeptidyl peptidase 9 (DPP9), and dipeptidyl peptidase 8 (DPP8) with IC50 values of 79, 1392, 6930 nM, respectively. Sulphostin causes phosphosulfamate modification, irreversibly inhibits the enzyme activity. Sulphostin can be used for inflammation and cancer study[1].
Product Specifications
UNSPSC
12352005
Target
Dipeptidyl Peptidase
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Smiles
[NH3+][C@@H]1C(N([P@](N)(NS(=O)([O-])=O)=O)CCC1)=O
Molecular Formula
C5H13N4O5PS
Molecular Weight
272.22
References & Citations
[1]Sewald L, et al. Sulphostin-inspired N-phosphonopiperidones as selective covalent DPP8 and DPP9 inhibitors. Nat Commun. 2025 Apr 3;16 (1) :3208.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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