SHP2-IN-44
SHP2-IN-44 (Compound 26) is an allosteric and orally active SHP2 inhibitor with an IC50 of 27 nM. SHP2-IN-44 also inhibits ERK phosphorylation (IC50 of 299 nM) without off-target hERG activity. SHP2-IN-44 has a broad-spectrum anticancer activity, such as juvenile myelomonocytic leukemia, neuroblastoma and breast cancer. SHP2-IN-44 can be used for Noonan syndrome, LEOPARD syndrome and cancers research[1].
Product Specifications
CAS Number
[2818955-47-2]
UNSPSC
12352005
Target
ERK; SHP2
Related Pathways
MAPK/ERK Pathway; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Field of Research
Cancer
Smiles
NC[C@@]1(C2=C(C=CC=C2)F)[C@]3([H])[C@@]1([H])CCN(C4=NC(N)=C(N=C4)SC5=CC=NC(N)=C5Cl)C3
Molecular Formula
C22H23ClFN7S
Molecular Weight
471.98
References & Citations
[1]Sferrazza A, et al. Novel azabicyclic series of potent SHP2 allosteric inhibitors. Bioorg Med Chem Lett. 2025 Aug 19;129:130383.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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