FIP22

FIP22 is a potent and selective IRAK4 PROTAC degrader (HEK293T cells: DC50 = 3.2 nM; THP-1 cells: DC50 = 10.6 nM) . FIP22 induces the ubiquitin-proteasome system by forming an IRAK4-FIP22-CRBN ternary complex (EC50 = 12.63 nM), thereby potently blocking IRAK4-mediated NF-κB and MAPK signaling pathways. FIP22 can be used for the study of atopic dermatitis (Pink: IRAK4 ligand (HY-175765) ; Blue: CRBN ligand (HY-W087383) ; Black: Linker (HY-46871) ) [1].

Product Specifications

CAS Number

[3091132-73-6]

UNSPSC

12352005

Target

Interleukin Related; IRAK; NF-κB; p38 MAPK; PROTACs; TNF Receptor

Related Pathways

Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; NF-κB; PROTAC

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Smiles

CC(NC1=CC(N2C=CC3=CC(C#N)=CN=C32)=NC=C1C(N[C@@H]4CC[C@H](CC4)C(N5CCC6(CC5)CCN(CC6)C7=CC=C(C8=C7)C(N(C8=O)C9C(NC(CC9)=O)=O)=O)=O)=O)C

Molecular Formula

C46H50N10O6

Molecular Weight

838.95

References & Citations

[1]Fan Y, et al. Discovery of Rigid Linker-Based IRAK4 PROTACs with Improved Metabolic Stability for the Treatment of Inflammatory Diseases. J Med Chem. 2025 Aug 28;68 (16) :17874-17896.