LRK-4189

LRK-4189 (Compound 319) is an orally active and selective PIP4K2C PROTAC degrader with a DC50 [1].

Product Specifications

CAS Number

[3063346-83-5]

UNSPSC

12352005

Target

PI5P4K; PROTACs

Related Pathways

Metabolic Enzyme/Protease; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=C1CC[C@@H](C(N1)=O)NC2=CC=C(C(F)=C2)N3CCN(CC3)[C@H]4CC[C@@H](CC4)C(N[C@H]5CC[C@@H](CC5)NC6=NC(C7=CC=CC(N8C=CC=CC8=O)=C7)=C(C=N6)F)=O

Molecular Formula

C43H49F2N9O4

Molecular Weight

793.90

References & Citations

[1]Krista Goodman, et al. Discovery of LRK-4189, a first-in-class degrader of the lipid kinase PIP4K2C for the treatment of Microsatellite Stable (MSS) Colorectal Carcinoma. ACS. 2025 Aug 20.|[2]Good A, et al. Inhibitors and degraders of pip4k protein. WO2024233846A1. 2024-11-14.