NGI-235
NGI-235 is a selective OST-A inhibitor that inhibits NF-κB inflammatory signaling by blocking TLR4 glycosylation[1].
Product Specifications
CAS Number
[2763063-40-5]
UNSPSC
12352100
Target
NF-κB
Related Pathways
NF-κB
Field of Research
Inflammation/Immunology
Purity
99.11
Smiles
O=C(C1=CC(S(=O)(N(CC2=CC=CC=C2)C)=O)=CC=C1N(CC3CC3)C)NC4=NC=C(CC)S4
Molecular Formula
C25H30N4O3S2
Molecular Weight
498.66
References & Citations
[1]Lampson BL, et al. Positive selection CRISPR screens reveal a druggable pocket in an oligosaccharyltransferase required for inflammatory signaling to NF-κB. Cell. 2024 Apr 25;187 (9) :2209-2223.e16.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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