ClpP modulator-1

ClpP modulator-1 (Compound BC8a), a peptidomimetic, is an allosteric ClpP modulator. ClpP modulator-1 is a ClpP activator at low concentration with EC50s of 0.35 and 0.58 μM for for Neisseria meningitides ClpP (NmClpP) and Escherichia coli ClpP (EcClpP), resepectively. ClpP modulator-1 also inhibits peptidase activity at high concentration by competitively inhibiting substrate protein (LY-AMC) binding to ClpP C sites. ClpP modulator-1 has antibacterial activity. ClpP modulator-1 can be used for bacterial infections research[1].

Product Specifications

CAS Number

[2363753-48-2]

UNSPSC

12352100

Target

ClpP

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Infection

Smiles

COC1=CC(Cl)=C(C=C1)C(N[C@H](C(N[C@H](B(O)O)CC(C)C)=O)CC(C)C)=O

Molecular Formula

C19H30BClN2O5

Molecular Weight

412.72

References & Citations

[1] Barghash MM, et al. Small molecule dysregulation of ClpP activity via bidirectional allosteric pathways. Structure. 2025 Aug 5:S0969-2126 (25) 00261-8.