DNMT2-IN-2
DNMT2-IN-2 is a selective DNA methyltransferase 2 (DNMT2) inhibitor with a KD value of 3.04 μM. DNMT2-IN-2 targets to a cryptic allosteric binding site of DNMT2. DNMT2-IN-2 reduces m5C levels in MOLM-13 tRNA and synergizes with Doxorubicin (HY-15142A) to impair cell viability. DNMT2-IN-2 can be used for cancer research, such as cervical cancer and leukemia[1].
Product Specifications
UNSPSC
12352100
Target
DNA Methyltransferase
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
NC(CNC(C[C@H](NC(C1(CC1)CNC(C2=CC(CC)=CC=C2)=O)=O)CC3=CC=C(C=C3)Cl)=O)=O
Molecular Formula
C26H31ClN4O4
Molecular Weight
499.00
References & Citations
[1]Frey AF, et al. DNA-encoded library screening uncovers potent DNMT2 inhibitors targeting a cryptic allosteric binding site. iScience. 2025 Aug 5;28 (9) :113300.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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