MLS6357
MLS6357 is a D3 dopamine receptor (D3R) -selective positive allosteric modulator (PAM) -antagonist. MLS6357 exhibits antagonist activity in the D3R-mediated and the BRET-based β-arrestin recruitment assay with IC50s of 13 and 14 μM, and no activity for other DAR subtypes (D1R/D2R/D4R/D5R) (IC50 > 100 μM) . MLS6357 is also an antagonist in the D3R-mediated Go-BRET assay with an IC50 of 17 μM. MLS6357 can be used for the study of neuropsychiatric disorders, including substance use disorder[1].
Product Specifications
CAS Number
[932544-59-7]
UNSPSC
12352005
Target
Dopamine Receptor; PERK
Related Pathways
Cell Cycle/DNA Damage; GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
O=C(C1=C(NC(C)=C1S(NC2=CC(Cl)=C(C=C2)C)(=O)=O)C)N3CCCC3
Molecular Formula
C18H22ClN3O3S
Molecular Weight
395.90
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
D1 Receptor; D2 Receptor; D3 Receptor; D4 Receptor; D5 Receptor
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