HI042
HI042 is a FMS-like Tyrosine Kinase 3 (FLT3) inhibitor. HI042 shows IC50 values of 0.62 μM for MOLM-13, 0.33 μM for MV4-11, and 0.89 μM for OCI-AML3 cells. HI042 selectively reduces the viability of FLT3-internal tandem duplication (FLT3-|TD) mutations-positive cell lines, induces apoptosis, disrupts cell cycle progression, and diminishes the clonogenic potential. HI042 can be used for the research of acute myeloid leukemia (AML) [1].
Product Specifications
CAS Number
[898168-15-5]
UNSPSC
12352100
Target
Apoptosis; FLT3
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
O=C(N/N=C/C1=CC=C([N+]([O-])=O)S1)/C=C/C2=CC=CC=C2
Molecular Formula
C14H11N3O3S
Molecular Weight
301.32
References & Citations
[1]de Miranda LBL, et al. Screening for Antileukemia Agents in FMS-like Tyrosine Kinase 3 (FLT3) -Mutated Acute Myeloid Leukemia Cells. ACS Pharmacol Transl Sci. 2025 Jul 22;8 (8) :2756-2766.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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