BER-IN-1

BER-IN-1 is a base excision repair (BER) inhibtor, targeting DNA abasic sites. BER-IN-1 cleaves abasic sites via β- and β, δ-elimination mechanisms, disrupts the base excision repair (BER) pathway and leads to DNA double-strand breaks (DSBs) . BER-IN-1 can enhance the effectiveness of the PARP inhibitor Olaparib (HY-10162) in homologous recombination (HR) -proficient cancer cells (MDA-MB-231, HeLa, and SKOV3) . BER-IN-1 induces an S-phase arrest and apoptosis companied with Olaparib (HY-10162) . BER-IN-1 can be used for the research of cancer, such as breast, cervical and ovarian cancer[1].