MRT-23227
MRT-23227 is a molecular glue degrader that targets cereblon (CRBN) . MRT-23227 forms a ternary complex with CRBN and G3BP2, activating the ubiquitin-proteasome system, leading to G3BP2 degradation. MRT-23227 has potential applications in the research of G3BP2-related cancers (such as breast and lung cancer) and neurodegenerative diseases[1].
Product Specifications
CAS Number
[3050683-03-6]
UNSPSC
12352005
Target
Molecular Glues
Related Pathways
PROTAC
Field of Research
Cancer; Neurological Disease
Smiles
O=C(C(C1=C(Cl)C(C2=CC=C(OCC3=NN(C)C=C3)C=C2)=CC=C1)CC4)NC4=O
Molecular Formula
C22H20ClN3O3
Molecular Weight
409.87
References & Citations
[1]Annunziato S, et al. Molecular surface mimicry enables CRBN to target G3BP2 for degradation. bioRxiv, 2025: 2025.04. 30.651496.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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MGAT1, CT (Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase, N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I, GNT-I, GlcNAc-T I, GGNT1, GLCT1, GLYT1, MGAT) (Azide free) (HRP) discontinued
