MRT-3486

MRT-3486 (Compound 5) is a cereblon-based NEK7 molecular glue degrader. MRT-3486 can be used for autoinflammatory diseases research[1].

Product Specifications

UNSPSC

12352005

Target

Molecular Glues; NEKs

Related Pathways

Cell Cycle/DNA Damage; PROTAC

Applications

COVID-19-anti-virus

Field of Research

Inflammation/Immunology

Purity

99.6200

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C([C@H]1N(S(=O)(CC2=CC=CC=C2)=O)CC3=C(C=CC=C3)C1)NCC4=CC5=NC=C(N(C(N6)=O)CCC6=O)N5C=C4

Molecular Formula

C29H28N6O5S

Molecular Weight

572.63

References & Citations

[1]Petzold G, et al. Mining the CRBN target space redefines rules for molecular glue-induced neosubstrate recognition. Science. 2025 Jul 3;389 (6755) :eadt6736.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

NEK7

Available Sizes

Curated Selection

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