Thalidomide-S-C6-acid
Thalidomide-S-C6-acid is a synthetic E3 ligase ligand -linker conjugate, consisting of a thalidomide-based cereblon ligand and one linker. It can be used to synthesize PROTAC Cas9 Degrader-1 (HY-172113) [1].
Product Specifications
CAS Number
[2378582-45-5]
UNSPSC
12352100
Target
E3 Ligase Ligand-Linker Conjugates
Related Pathways
PROTAC
Field of Research
Cancer
Smiles
O=C(O)CCCCCCSC1=CC=CC2=C1CN(C(CC3)C(NC3=O)=O)C2=O
Molecular Formula
C20H24N2O5S
Molecular Weight
404.48
References & Citations
[1]Sun S, et al. PROTAC molecule-mediated SpCas9 protein degradation for precise genome editing. bioRxiv, 2025: 2025.01. 07.631496.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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