MRT-7612

MRT-7612 (Compound 4) is a cereblon-based tyrosine kinases molecular glue degrader. MRT-7612 significantly induces HCK and LYN degradation, with week efficacy on LCK. MRT-7612 can be used for cancers like chronic myeloid leukemia, autoimmune and chronic inflammatory diseases research[1].

Product Specifications

UNSPSC

12352005

Target

Bcr-Abl; Molecular Glues; Src

Related Pathways

PROTAC; Protein Tyrosine Kinase/RTK

Field of Research

Cancer; Inflammation/Immunology

Smiles

O=C(N1CC2(CCC3=C2C=CC=C3)C1)NC4=CC=CC5=C4CN(C(CC6)C(NC6=O)=O)C5=O

Molecular Formula

C25H24N4O4

Molecular Weight

444.48

References & Citations

[1]Petzold G, et al. Mining the CRBN target space redefines rules for molecular glue-induced neosubstrate recognition. Science. 2025 Jul 3;389 (6755) :eadt6736.