ArMan
ArMan is an aryl mannoside ligand that can be chemically functionalized onto the surface of virus-like particles (VLPs) through click chemistry. VLPs can be used to target DC-SIGN dendritic cells, promote the selective co-binding of DC-SIGN and TLR7, and lead to a Th1-type immune response. VLP-ArMan-OvaI/II can significantly inhibit tumor growth in the mouse melanoma model[1].
Product Specifications
UNSPSC
12352005
Target
Others
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
OC[C@H]([C@H]([C@@H]1O)O)O[C@@H]([C@H]1O)OC2=CC=C(CCNC(CCC#C)=O)C=C2
Molecular Formula
C19H25NO7
Molecular Weight
379.40
References & Citations
[1]Lensch V, et al. Carbohydrate-Lectin Interactions Reprogram Dendritic Cells to Promote Type 1 Anti-Tumor Immunity. ACS Nano. 2024 Oct 1;18 (39) :26770-26783.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
