Dth

Dth is a RNA aptamer-based PROTAC degrader. Dth can degrade a range of endogenous proteins (such as mCherry, p50, p65 and E2F1) by simply replacing the 3′ module on the RNA scaffold with the corresponding RNA aptamer of target protein (target aptamer) [1]. Pink: Target aptamer ligand (HY-176801) ; Blue: CRBN ligase ligand (HY-41547) ; Black: linker (HY-79577) .

Product Specifications

Product Name Alternative

DFHBI-thalidomide

UNSPSC

12352005

Target

Early 2 Factor (E2F) ; NF-κB; PROTACs

Related Pathways

Cell Cycle/DNA Damage; NF-κB; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3NCCCCCCN(C(C)=N/C4=C\C5=CC(F)=C(O)C(F)=C5)C4=O)=O

Molecular Formula

C30H29F2N5O6

Molecular Weight

593.58

References & Citations

[1]Xu Y, et al. A heterobifunctional molecule recruits cereblon to an RNA scaffold and activates its PROTAC function[J]. Cell Reports Physical Science, 2022, 3 (10) .