QPyN16Th
QPyN16Th is an N-palmitoylated cationic thiazolidine antibiotic. QPyN16Th is selectively active against the Gram-positive bavteria E. faecalis, S. aureus and MRSA with an MIC of 1.95 μM over gram-negative bacteria. QPyN16Th can induce membrane permeabilization and depolarization and ROS production in MRSA. QPyN16Th increases the survival of zebrafish model of intramuscular MRSA infection[1].
Product Specifications
UNSPSC
12352005
Target
Antibiotic; Bacterial
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Smiles
O=C(N1C(C2=[N+](C=CC=C2)C)SCC1)CCCCCCCCCCCCCCC.[I-]
Molecular Formula
C25H43IN2OS
Molecular Weight
546.59
References & Citations
[1]Pious, A., et al., (2024) . Synthesis of cationic N-acylated thiazolidine for selective activity against Gram-positive bacteria and evaluation of N-acylation's role in membrane-disrupting activity. RSC medicinal chemistry.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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