DMU759
DMU759 is a Lysyl-tRNA synthetase 1 (KRS1) inhibitor. DMU759 has potent anti-kinetoplastid activity against Trypanosoma cruzi , Trypanosoma brucei and Leishmania donovani. DMU759 significantly reduces parasitemia in acute Chagas disease mice model. DMU759 can be used for parasitic infection like Chagas disease research[1].
Product Specifications
CAS Number
[3052352-22-1]
UNSPSC
12352005
Target
Parasite
Related Pathways
Anti-infection
Field of Research
Infection
Smiles
NC1=C2C(F)=C(F)C(SC3CCCCC3)=C(F)C2=NC(C)=N1
Molecular Formula
C15H16F3N3S
Molecular Weight
327.37
References & Citations
[1]Tulloch LB, et al. Antitrypanosomal quinazolines targeting lysyl-tRNA synthetase show partial efficacy in a mouse model of acute Chagas disease. Sci Transl Med. 2025 Jul 9;17 (806) :eadu4564.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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