BAL-1516
BAL-1516 is a brain-penetrant and highly selective NLRP3 inhibitor (IC50=14.2 nM) . BAL-1516 significantly suppresses IL-1β and IL-18 release in microglial neuroinflammation models (IC50=11-59 nM) . BAL-1516 is promising for research of neurodegenerative diseases (e.g., Alzheimer’s, Parkinson’s) and systemic inflammatory disorders[1].
Product Specifications
UNSPSC
12352005
Target
NOD-like Receptor (NLR)
Related Pathways
Immunology/Inflammation
Field of Research
Inflammation/Immunology; Neurological Disease
Smiles
CCOC1=CC(C(N([C@@H](C2=CN=C(C3=C2NN=C3)C)C)C)=O)=CC=C1C4=NC(C)=CS4
Molecular Formula
C23H25N5O2S
Molecular Weight
435.54
References & Citations
[1]Torp J, et al. Inhibition of NLRP3 by a CNS-penetrating indazole scaffold[J]. bioRxiv, 2025: 2025.07. 01.662566.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NLRP3
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