MI891
MI891 is a highly selective PXR antagonist (IC50 = 3.76 μM, Kd = 1.7 μM) and inverse agonist (IC50 = 6.1 μM) . MI891 selectively disrupts the interaction between PXR and its coactivator SRC1. MI891 effectively inhibits Rifampicin (HY-B0272) -induced PXR activation. MI891 is useful for the study of metabolic diseases and other diseases[1].
Product Specifications
CAS Number
[2530027-77-9]
UNSPSC
12352005
Target
Cytochrome P450; Pregnane X Receptor (PXR)
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Field of Research
Metabolic Disease
Smiles
O=C(N)C1=CC(CN2N=NC(C3=C(C4=CC=C(Cl)C=C4)N=C5C(F)=CC(F)=CN53)=C2)=CC=C1Cl
Molecular Formula
C23H14Cl2F2N6O
Molecular Weight
499.30
References & Citations
[1]Kamaraj R, et al. Discovery of PXR Antagonist MI891 and PXR Degrader MI1013 and Their Roles in Hepatic Gene Regulation. J Med Chem. 2025 Jul 24;68 (14) :14271-14299.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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