WHN-11

WHN-11 is an amino-Artemisinin (HY-B0094) derivative with anti-cancer activity against various cancer cell lines. WHN-11 deprives the cell of ATP, activates autophagy, and causes subsequent cell death by apoptosis. WHN-11 alters cellular protein homeostasis pathways to induce mitochondrial fission and dysfunction. WHN-11's anti-cancer activity is independent of substantive ROS production. WHN-11 can be used for the study of triple-negative breast cancer (TNBC) [1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; Autophagy

Related Pathways

Apoptosis; Autophagy

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

C[C@@H]1[C@@]2([H])[C@]34[C@](O[C@](OO3)(CC[C@@]4([H])[C@@H](CC2)C)C)([H])O[C@H]1N5CCN(CC5)C(NC6=CC=C(C=C6)C(F)(F)F)=O

Molecular Formula

C27H36F3N3O5

Molecular Weight

539.59

References & Citations

[1]Kajewole D, et al. The novel amino-artemisinin derivative WHN-11 disrupts mitochondria and protein homeostasis, and induces autophagy and apoptosis in cancer cells. Sci Rep. 2025 Jul 1;15 (1) :21604.