Topi MF-6
Topi MF-6 is a DNA topoisomerase I (Top1) inhibitor. Topi MF-6 has superior cytotoxicity against gastrointestinal cancer cells. Topi MF-6 can be used as an ADC payload[1].
Product Specifications
CAS Number
[2944016-96-8]
UNSPSC
12352005
Target
ADC Payload; Topoisomerase
Related Pathways
Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
99.79
Smiles
CC[C@@](C1=C(CO2)C(N3CC4=C5C6=C(CCC5(F)F)C(N)=CC=C6N=C4C3=C1)=O)(O)C2=O
Molecular Formula
C23H19F2N3O4
Molecular Weight
439.41
References & Citations
[1]Wang R, et al. Overcoming multidrug resistance in gastrointestinal cancers with a CDH17-targeted ADC conjugated to a DNA topoisomerase inhibitor. Cell Rep Med. 2025 Jul 15;6 (7) :102213.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Topo I
Available Sizes
Curated Selection
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