SufS-IN-1

SufS-IN-1, a (2R,3R) -3-ethoxycarbonylaziridine-2-carboxylic acid (EAC), is a selective Cysteine desulfurase type II (SufS) inhibitor. SufS-IN-1 significantly inhibits the SufS activity by covalently binding to the cofactor PLP to form a stable PLP-ligand conjugates. SufS-IN-1 can be used for pathogenic microorganisms research, such as Plasmodium falciparum, Staphylococcus aureus and Mycobacterium tuberculosis[1].

Product Specifications

CAS Number

[167933-78-0]

UNSPSC

12352211

Target

Bacterial; Parasite

Related Pathways

Anti-infection

Field of Research

Infection

Smiles

O=C([C@]1([H])N[C@@]1([H])C(OCC)=O)O

Molecular Formula

C6H9NO4

Molecular Weight

159.14

References & Citations

[1]Fujishiro T, et al. Discovery of an Aziridine-Based Inhibitor That Targets Cysteine Desulfurase Type II SufS via High-Throughput X-ray Crystallography[J]. ACS Medicinal Chemistry Letters, 2025.