Anticancer agent 276

Anticancer agent 276 (Compound 5) is a multi-target anticancer agent. Anticancer agent 276 has a potent anticancer activity against human tumor cells with IC50s of 6.90 and 4.48 μM for HEPG2 and MCF7 cells, respectively. Anticancer agent 276 shows strong and stable interactions across multiple targets, including Topoisomerase II, VEGFR2, c-Met, EGFR and ERα[1].

Product Specifications

UNSPSC

12352005

Target

C-Met/HGFR; EGFR; Estrogen Receptor/ERR; Topoisomerase; VEGFR

Related Pathways

Cell Cycle/DNA Damage; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Vitamin D Related/Nuclear Receptor

Field of Research

Cancer

Smiles

NN1C(C2=C(N=C1[C@H]3CC(C4=CC=CC=C4)=NN[C@H]3C5=CC=CC=C5)C=CC=C2)=O

Molecular Formula

C24H21N5O

Molecular Weight

395.46

References & Citations

[1]Haneen DSA, et al. Synthesis, comprehensive in silico studies, and cytotoxicity evaluation of novel quinazolinone derivatives as potential anticancer agents. Sci Rep. 2025 Jul 3;15 (1) :23697.