Urease-IN-21

Urease-IN-21 (Compound 11b) is a Urease inhibitor with an IC50 of 0.12 μM. Urease-IN-21 has potent antibacterial activity against helicobacter pylori (H. pylori) and inhibitor activity against P450 enzyme (CYP2C19, CYP2C9, and CYP3A4) . Urease-IN-21 can be used for H. pylori infection research[1].

Product Specifications

UNSPSC

12352005

Target

Bacterial; Urease

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Smiles

CC1=CC=C(C=C1)S(=O)(N(C2=CC=CC=C2)CC3=CN(CC(NC4=C(C)C=CC=C4)=O)N=N3)=O

Molecular Formula

C25H25N5O3S

Molecular Weight

475.56

References & Citations

[1]Varzaneh SB, et al. Design, synthesis, and anti-urease evaluations of new sulfonamide-1,2,3-triazole-acetamide derivatives. Sci Rep. 2025 Jul 2;15 (1) :22565.