Pt (II) -NHC complex 2C

Pt (II) -NHC Complex 2C (Platinum (II) -N-Heterocyclic Carbene complex 2C) (Compound 2C) is a platinum (II) complex based on N-heterocyclic carbene (NHC) . Pt (II) -NHC Complex 2C is an immunogenic cell death (ICD) inducer that can induce endoplasmic reticulum stress (ERS) in liver cancer cells and produce reactive oxygen species (ROS), ultimately leading to the release of damage-associated molecular patterns (DAMP) . Pt (II) -NHC Complex 2C blocks the cell cycle at the S phase and significantly induces cell apoptosis. Pt (II) -NHC Complex 2C shows anti-liver cancer potential in mouse models and activates immune cells in liver injury models.

Product Specifications

CAS Number

[3035433-94-1]

Product Name Alternative

Platinum (II) -N-heterocyclic carbene complex 2C

UNSPSC

12352005

Target

Apoptosis; ER-phagy; Reactive Oxygen Species (ROS)

Related Pathways

Apoptosis; Autophagy; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Field of Research

Cancer

Smiles

I[Pt](I)([N]1=CC=CC=C1)=C(N2CC)N(CC)C(C3=CC=C(F)C=C3)=C2C4=CC=C(F)C=C4

Molecular Formula

C24H23F2I2N3Pt

Molecular Weight

840.35

References & Citations

[1]Bian M, et al. Pt (II) -NHC Complex Induces ROS-ERS-Related DAMP Balance to Harness Immunogenic Cell Death in Hepatocellular Carcinoma. J Med Chem. 2022 Feb 10;65 (3) :1848-1866.