QNX-10
QNX-10 is a fatty acid synthase (FASN) inhibitor (IC50 = 0.7 μM) with anticancer activity. QNX-10 exhibits potent FASN inhibition and cytotoxicity against colorectal and breast cancer cells. QNX-10 induces apoptosis and cell cycle arrest in S phase by upregulating the pro-apoptotic protein Bax and downregulating the anti-apoptotic protein Bcl-xL. QNX-10 can be used to investigate anticancer therapies targeting FASN enzymes[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Bcl-2 Family; Fatty Acid Synthase (FASN)
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
FC1=CC=C(C2=CN=C(C=C(C(N3CCN(C(C4OCCC4)=O)CC3)=O)C=C5)C5=N2)C=C1
Molecular Formula
C24H23FN4O3
Molecular Weight
434.46
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Bax; Bcl-xL
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