KPC-2-IN-3

KPC-2-IN-3 (Compound 3b) is a KPC-2 inhibitor with IC50 of 0.533 μM and Kiof 0.194 μM. KPC-2-IN-3 has an antimicrobial activity against carbapenem-resistant K. pneumonia K47-25 and reduces bacterial count with a postantibiotic effect in synergy with Meropenem (HY-13678) . KPC-2-IN-3 significantly reduces lung bacterial load in a murine pneumonia model[1].

Product Specifications

UNSPSC

12352128

Target

Bacterial

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Smiles

FC1=CC=C(C(B(O)O)=C1)/C=C/P(O)(O)=O

Molecular Formula

C8H9BFO5P

Molecular Weight

245.94

References & Citations

[1]Singh M, et al. Design and SAR Analysis of Phenylboronic Acid-Based Inhibitors for Sensitizing KPC-2-Producing Klebsiella pneumoniae to β-Lactam Antibiotics. J Med Chem. 2025 Jul 10;68 (13) :13421-13435.