JY-21
JY-21 is a BRD4 PROTAC degrader with a DC50 of 3.797 μM. JY-21 has a potent anticancer activity against MDA-MB-231 cells[1]. Pink: BRD4 ligand (HY-78695) ; Blue: E3 ligase ligand (HY-174994) ; Black: linker (HY-151862)
Product Specifications
UNSPSC
12352100
Target
Epigenetic Reader Domain; PROTACs
Related Pathways
Epigenetics; PROTAC
Field of Research
Cancer
Smiles
CC1=C(C(C(C2=CC=C(C=C2)Cl)=N[C@H]3CC(NCCCN4C=C(N=N4)COC5=CC=C(C([N+]([O-])=O)=C5)/N=N/C#C[Si](C(C)C)(C(C)C)C(C)C)=O)=C(N6C3=NN=C6C)S1)C
Molecular Formula
C42H50ClN11O4SSi
Molecular Weight
868.52
References & Citations
[1] Du J, et al. Azoacetylene Electrophiles for Proteome-wide Ligand and Target Discovery: Supporting Targeted Protein Degradation. J Med Chem. 2025 Jul 10;68 (13) :13516-13531.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BRD4
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